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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
22.73
Human Site:
S1043
Identified Species:
31.25
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S1043
H
K
E
I
S
K
I
S
L
H
P
I
E
D
N
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S1043
H
K
E
I
S
K
I
S
L
H
P
I
E
D
N
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S1042
H
K
E
I
S
K
I
S
L
H
P
I
E
D
N
Dog
Lupus familis
XP_535848
1288
147094
S1043
Q
K
E
I
G
K
I
S
L
H
P
I
E
N
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
K1041
Q
K
E
I
S
K
I
K
L
H
P
V
E
D
N
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
A977
S
S
I
Y
A
R
E
A
L
I
E
I
D
Y
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
E834
E
I
S
S
L
S
Q
E
D
L
E
A
I
K
D
Chicken
Gallus gallus
NP_989849
1274
145838
I1014
Q
K
E
I
S
K
I
I
M
H
P
I
E
D
K
Frog
Xenopus laevis
P50532
1290
146971
S1037
Q
K
E
I
T
K
I
S
L
H
K
I
E
D
I
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
C1042
Q
K
E
A
S
K
L
C
L
H
H
I
D
G
V
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
S1038
Q
K
E
A
S
K
L
S
L
H
T
I
E
D
N
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
E1403
E
L
Q
G
K
L
D
E
S
N
T
V
L
E
S
Honey Bee
Apis mellifera
XP_396862
1282
148175
G963
D
E
Y
K
I
I
P
G
E
N
V
E
E
L
I
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
D1134
Y
E
N
V
D
G
E
D
R
V
P
V
E
L
L
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
E1041
K
K
E
L
G
K
L
E
I
H
I
L
D
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
Q985
K
K
K
L
N
D
L
Q
I
A
F
T
K
H
M
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
S1118
E
K
G
L
N
E
L
S
I
R
D
V
T
H
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
80
N.A.
80
13.3
N.A.
0
73.3
73.3
46.6
73.3
0
6.6
13.3
26.6
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
40
N.A.
6.6
80
80
60
80
33.3
20
40
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
6
0
0
6
0
6
0
6
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% C
% Asp:
6
0
0
0
6
6
6
6
6
0
6
0
18
42
6
% D
% Glu:
18
12
59
0
0
6
12
18
6
0
12
6
59
6
6
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% F
% Gly:
0
0
6
6
12
6
0
6
0
0
0
0
0
6
6
% G
% His:
18
0
0
0
0
0
0
0
0
59
6
0
0
12
0
% H
% Ile:
0
6
6
42
6
6
42
6
18
6
6
53
6
0
12
% I
% Lys:
12
71
6
6
6
59
0
6
0
0
6
0
6
6
6
% K
% Leu:
0
6
0
18
6
6
30
0
53
6
0
6
6
12
6
% L
% Met:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
6
% M
% Asn:
0
0
6
0
12
0
0
0
0
12
0
0
0
6
36
% N
% Pro:
0
0
0
0
0
0
6
0
0
0
42
0
0
0
0
% P
% Gln:
36
0
6
0
0
0
6
6
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
6
0
0
6
6
0
0
0
6
0
% R
% Ser:
6
6
6
6
42
6
0
42
6
0
0
0
0
0
6
% S
% Thr:
0
0
0
0
6
0
0
0
0
0
12
6
6
0
6
% T
% Val:
0
0
0
6
0
0
0
0
0
6
6
24
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
6
6
0
0
0
0
0
0
0
0
0
6
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _